Human Recombinant TGF-beta1 (from CHO cells)Supplier: PeproTech
AF10021C50UG AF10021C100UG AF10021C2UG AF10021C10UG AF10021C250UG AF10021C1MG AF10021C500UG
10778-036EA 1349.12 CAD10778-036 10778-038 10778-032 10778-034 10778-040 10778-044 10778-042
Human Recombinant TGF-beta1 (from CHO cells)
Proteins and Peptides
The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.