Human Recombinant TPO (from E. coli)Supplier: PeproTech
AF3001810UG AF30018100UG AF30018500UG AF3001850UG AF30018250UG AF300182UG AF300181MG
10778-652EA 408.54 CAD10778-652 10778-656 10778-660 10778-654 10778-658 10778-650 10778-662
Human Recombinant TPO (from E. coli)
Proteins and Peptides
TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. The human TPO gene encodes for a 353 amino acid glycoprotein, which contains a 21 amino acid signal sequence, a 15 amino acid erythropoietin-like domain, and a highly glycosylated 179 amino acid C-terminal domain. Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.