Human Recombinant TGF-beta2 (from (BTI-Tn-5B1-4) Hi-5 Insect cells)

Supplier: PeproTech

100-35-1MG 100-35-10UG 100-35-100UG 100-35-2UG 100-35-500UG 100-35-250UG
10778-922EA 9995.63 CAD
10778-922 10778-914 10778-916 10778-912 10778-920 10778-918
Human Recombinant TGF-beta2 (from (BTI-Tn-5B1-4) Hi-5 Insect cells)
Proteins and Peptides
The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2-dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant Human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.
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