Human Recombinant HGF (from (BTI-Tn-5B1-4) Hi-5 Insect cells)Supplier: PeproTech
100-39-10UG 100-39-1MG 100-39-50UG 100-39-100UG 100-39-2UG 100-39-250UG 100-39-500UG
10778-954EA 379.79 CAD10778-954 10778-964 10778-956 10778-958 10778-952 10778-960 10778-962
Human Recombinant HGF (from (BTI-Tn-5B1-4) Hi-5 Insect cells)
Proteins and Peptides
HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF is an 80.0 kDa polypeptide consisting of 697 amino acid residues.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.