Recombinant Human R-Spondin-3, Peprotech, Inc.Supplier: Peprotech
120-44-5UG 120-44-20UG 120-44-100UG 120-44-250UG 120-44-500UG 120-44-1MG
10779-274EA 153.96 CAD10779-274 10779-276 10779-278 10779-280 10779-282 10779-284
Recombinant Human R-Spondin-3, Peprotech, Inc.
Proteins and Peptides
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant Human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.