Human Recombinant sIL-2Ra (from (BTI-Tn-5B1-4) Hi-5 Insect cells)Supplier: PeproTech
200-02R-100UG 200-02R-5UG 200-02R-1MG 200-02R-500UG 200-02R-50UG 200-02R-250UG
10779-582EA 1051.29 CAD10779-582 10779-576 10779-588 10779-586 10779-580 10779-584
Human Recombinant sIL-2Ra (from (BTI-Tn-5B1-4) Hi-5 Insect cells)
Proteins and Peptides
The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Rα, IL-2Rβ, and IL-2Rγ. The IL-2Rα is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2Rα releases the entire extracellular domain of IL-2Rα, thereby generating a 219 amino acid soluble protein called soluble IL-2Rα (sIL-2Rα). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2Rα is expressed on leukemia cells, lymphoma cells, and newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant Human sIL-2 Receptor α is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2Rα. Due to glycosylation, IL-2Rα has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.