Human Recombinant sRANK (from E. coli)Supplier: PeproTech
310-01-250UG 310-01-100UG 310-01-500UG 310-01-1MG 310-01-50UG
10780-628EA 3415.97 CAD10780-628 10780-626 10780-630 10780-632 10780-624
Human Recombinant sRANK (from E. coli)
Proteins and Peptides
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. Recombinant Human sRANK Ligand is a 20.0 kDa polypeptide comprising the TNF-homologous region of RANKL (176 amino acid residues).
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.