Human Recombinant MANF (from E. coli)Supplier: PeproTech
450-06-250UG 450-06-5UG 450-06-25UG 450-06-500UG 450-06-1MG 450-06-100UG
10781-212EA 1970.75 CAD10781-212 10781-206 10781-208 10781-214 10781-216 10781-210
Human Recombinant MANF (from E. coli)
Proteins and Peptides
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain an N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.