Human Recombinant PDGF-AA (from E. coli)Supplier: PeproTech
AF10013A1MG AF10013A10UG AF10013A100UG AF10013A500UG AF10013A250UG AF10013A50UG AF10013A2UG
10781-678EA 8070.66 CAD10781-678 10771-708 10781-672 10781-676 10781-674 10771-710 10771-706
Human Recombinant PDGF-AA (from E. coli)
Proteins and Peptides
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two α chains (250 total amino acids).
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.