(Arg6)-beta-Amyloid (1-40) Trifluoroacetate, BachemSupplier: BACHEM AMERICAS INC
H-7336.0500BAEA 563.99 CADH-7336.0500BA
(Arg6)-beta-Amyloid (1-40) Trifluoroacetate, Bachem
Proteins and Peptides
The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His⁶ by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.