(Pyr3)-beta-Amyloid (3-40) Trifluoroacetate, Bachem


4050043.1000 4050043.0500
10796-764EA 806.57 CAD
10796-764 10796-762
(Pyr3)-beta-Amyloid (3-40) Trifluoroacetate, Bachem
Proteins and Peptides
The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
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