Anti-IL12B Rabbit Polyclonal Antibody [clone: 21HCLC]

Supplier: Pierce Biotechnology
CAPI710257EA 1546.67 CAD
Anti-IL12B Rabbit Polyclonal Antibody [clone: 21HCLC]
This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology. ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale and purified with Protein A. ABfinity™ oligoclonal antibodies comprise a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds—the sensitivity of a polyclonal antibody with the specificity of a monoclonal, all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody—recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets when compared with monoclonal antibodies—an oligoclonal antibody has a known mixture of light and heavy chains. This exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. IL-12 (Interleukin 12) is produced primarily by macrophages, neutrophils, and dendritic cells. It is a disulphide linked heterodimeric cytokine with a 40 KDa subunit (p40) and a 35 KDa subunit. IL-12 is a regulatory cytokine important for mediating cellular immune responses. It helps in induction of cytotoxic activities, proliferation, and Th1 cell development. Human and mouse IL12 p40 share about 70% amino acid sequence homology.

Recommended Dilutions: Western Blot: 1-3 ?g/ml

Type: Primary
Antigen: IL12B
Clonality: Polyclonal
Clone: 21HCLC
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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