Anti-MAP2K1 Rabbit Polyclonal Antibody [clone: 13HCLCP]

Supplier: Pierce Biotechnology
CAPI710291EA 1546.67 CAD
Anti-MAP2K1 Rabbit Polyclonal Antibody [clone: 13HCLCP]
This antibody is predicted to react with mouse, rat, Drosophila, non-human primate and rabbit based on sequence homology. ABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale and purified with Protein A. ABfinity™ oligoclonal antibodies comprise a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds—the sensitivity of a polyclonal antibody with the specificity of a monoclonal, all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody—recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets when compared with monoclonal antibodies—an oligoclonal antibody has a known mixture of light and heavy chains. This exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. MAP2K1 is a dual specificity mitogen-activated protein kinase (MAPK) kinase. It is an essential component of the MAP kinase pathway and stimulates the enzymatic activity of MAP kinases in response to various signals. Growth factors, cytokines, and proto-oncogenes transduce their signals through the activation of RAS, which leads to activation of the serine/threonine kinase RAF, and then to activation of MAPK kinase. MAP2K1 is activated by the Raf family member p74raf-1, through phosphorylation of serine residues at positions 217 and 221 in the activation loop.

Recommended Dilutions: Western Blot: 1-3µg/ml

Type: Primary
Antigen: MAP2K1
Clonality: Polyclonal
Clone: 13HCLCP
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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