Anti-CBFA2T2 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology
PA535169
CAPIPA535169EA 1960.37 CAD
CAPIPA535169
Anti-CBFA2T2 Rabbit Polyclonal Antibody
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence: 1:10-1:50, Immunocytochemistry: 1:10-1:50

Type: Primary
Antigen: CBFA2T2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR