Anti-AKT1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA512540
CAPIPA5-12540EA 2286.72 CAD
CAPIPA5-12540
Anti-AKT1 Rabbit Polyclonal Antibody
Antibodies
This antibody is predicted to react with mouse and rat based on sequence homology. The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: AKT1 (v-akt murine thymoma viral oncogene homolog 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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