Anti-SMAD3 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA512693
CAPIPA5-12693EA 2800.97 CAD
CAPIPA5-12693
Anti-SMAD3 Rabbit Polyclonal Antibody
Antibodies
This antibody is predicted to react with chicken, mouse, porcine and rat based on sequence homology. SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.

Recommended Dilutions: Immunofluorescence: 1:10-1:50, Dot blot: 1:500

Type: Primary
Antigen: SMAD3 (SMAD family member 3)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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