Anti-PI3KC3 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA512829
CAPIPA5-12829EA 2573.22 CAD
CAPIPA5-12829
Anti-PI3KC3 Rabbit Polyclonal Antibody
Antibodies
This antibody is predicted to react with mouse, porcine and rat based on sequence homology. PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: PI3KC3
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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