Anti-TSC1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA512900
CAPIPA5-12900EA 2573.22 CAD
CAPIPA5-12900
Anti-TSC1 Rabbit Polyclonal Antibody
Antibodies
This antibody is predicted to react with mouse based on sequence homology. TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: TSC1 (tuberous sclerosis 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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