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Specifications
- Antibody type:Primary
- Antigen name:Tuberous sclerosis 2 protein
- ChIP:Yes
- Clonality:Polyclonal
- Gel shift:Yes
- Host:Rabbit
- Isotype:IgG
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:TSC2
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:TSC4,LAM,TSC2,Tuberous sclerosis 2 protein,Tuberin
- Modification:phospho-Ser1798
- Storage buffer:PBS with 0.09% Sodium azide
- Molecular weight:200.75 kDa
- Storage temperature:Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at –20 °C
- Concentration:Lot-specific
- Immunogen:KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1798 of human TSC2
- Tested applications:Dot Blot
- Purification:Antigen affinity chromatography
- Cat. no.:CAPIPA5-12908
Specifications
About this item
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Recommended Dilutions: Immunofluorescence: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Dot blot: 1:500
Type: Primary
Antigen: TSC2 (tuberous sclerosis 2)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human