Anti-INSR Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

CAPIPA5-12983EA 2573.22 CAD
Anti-INSR Rabbit Polyclonal Antibody
This antibody is predicted to react with bovine, canine, mouse, rat and Xenopus based on sequence homology. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: INSR (insulin receptor)
Clonality: polyclonal
Conjugation: unconjugated
Host: Rabbit
Isotype: none
Reactivity: Human
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