Anti-NANOG Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA513079
CAPIPA5-13079EA 2286.72 CAD
CAPIPA5-13079
Anti-NANOG Rabbit Polyclonal Antibody
Antibodies
NANOG is a Ttranscription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: NANOG (Nanog homeobox)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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