Anti-ABCB11 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA513105
CAPIPA5-13105EA 2801.79 CAD
CAPIPA5-13105
Anti-ABCB11 Rabbit Polyclonal Antibody
Antibodies
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000

Type: Primary
Antigen: ABCB11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Human
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