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Specifications
- Antibody type:Primary
- Antigen name:Matrix Metalloproteinase 12
- ChIP:Yes
- Clonality:Polyclonal
- Gel shift:Yes
- Gene ID:MMP12/4321; Mmp12/17381
- Host:Rabbit
- Isotype:IgG
- Neutralisation:Yes
- Reactivity:Human,Mouse
- Antigen symbol:MMP12
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:400 µL
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:matrix metalloproteinase 12,MGC138506,macrophage metalloelastase,MME,HME,matrix metalloproteinase 12 (macrophage elastase),macrophage elastase,MMP12,matrix metallopeptidase 12 (macrophage elastase)
- Storage buffer:PBS with 0.09% Sodium azide
- Molecular weight:54 kDa
- Storage temperature:Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at –20 °C
- Concentration:Lot-specific
- Immunogen:KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12
- Tested applications:Immunohistochemistry
- Purification:Ammonium sulfate precipitation, Size-exclusion - Dialysis
- Cat. no.:CAPIPA5-13181
Specifications
About this item
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.
Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry: 1:50-1:100
Type: Primary
Antigen: MMP12 (matrix metallopeptidase 12 (macrophage elastase))
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human