Anti-WISP2 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA513232
CAPIPA5-13232EA 2573.22 CAD
CAPIPA5-13232
Anti-WISP2 Rabbit Polyclonal Antibody
Antibodies
Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Recommended Dilutions: Western Blot: 1:1000, Immunohistochemistry: 1:50-1:100

Type: Primary
Antigen: WISP2 (WNT1 inducible signaling pathway protein 2)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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