Anti-PARP6 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology
PA513291
CAPIPA5-13291EA 2561.45 CAD
CAPIPA5-13291
Anti-PARP6 Rabbit Polyclonal Antibody
This antibody is predicted to react with mouse based on sequence homology. Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Recommended Dilutions: Western Blot: 1:1000

Type: Primary
Antigen: PARP6 (poly (ADP-ribose) polymerase family, member 6)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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