Anti-APH1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology
PA513316
CAPIPA5-13316EA 2561.45 CAD
CAPIPA5-13316
Anti-APH1 Rabbit Polyclonal Antibody
This antibody is predicted to react with mouse based on sequence homology. APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000

Type: Primary
Antigen: APH1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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