Anti-GPC3 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

CAPIPA5-13360EA 2801.79 CAD
Anti-GPC3 Rabbit Polyclonal Antibody
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence: 1:10-1:50

Type: Primary
Antigen: GPC3 (glypican 3)
Clonality: polyclonal
Conjugation: unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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