Anti-VHL Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA513488
CAPIPA5-13488EA 2801.79 CAD
CAPIPA5-13488
Anti-VHL Rabbit Polyclonal Antibody
Antibodies
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.

Recommended Dilutions: Western Blot: 1:1000, Immunohistochemistry: 1:50-1:100, Flow Cytometry: 1:10-1:50

Type: Primary
Antigen: VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human
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