Anti-MARK1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology
PA513945
CAPIPA5-13945EA 2444.36 CAD
CAPIPA5-13945
Anti-MARK1 Rabbit Polyclonal Antibody
MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK.

Recommended Dilutions: Western Blot: 1:1000, Immunohistochemistry: 1:10-1:50

Type: Primary
Antigen: MARK1 (MAP/microtubule affinity-regulating kinase 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity:
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