Anti-PDXK Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology
CAPIPA5-13971EA 2561.45 CAD
Anti-PDXK Rabbit Polyclonal Antibody
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

Recommended Dilutions: Western Blot: 1:1000, Immunohistochemistry: 1:50-1:100

Type: Primary
Antigen: PDXK (pyridoxal (pyridoxine, vitamin B6) kinase)
Clonality: polyclonal
Conjugation: unconjugated
Host: Rabbit
Isotype: none
Reactivity: Human
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