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CD40L [CD154] Recombinant Protein, Prosci

Supplier: Prosci

CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein that belongs to the TNF superfamily. As with other TNF superfamily members, CD40L will exist as a trimer, both as a membrane bound and soluble form. Multiple mutations and alternate splice forms of CD40L exist, often associated with pathology and leading to truncated or nontrimerizable forms of CD40L. CD40L binds to both CD40 and to integrin alphaIIbbeta3 (CD41). In the cell membrane, it also associates with a unique splice variant of CD28 (CD28i) that may facilitate CD40L signal transduction. CD40L is expressed by monocytes, NK cells, mast cells, basophils, smooth muscle cells, endothelial cells, dendritic cells,activated and resting B cells, plus activated platelets and CD4+ T cells. CD40L ligation of CD40 on dendritic cells (DC) initiates DC maturation and differentiation. CD40L signaling into naive B cells promotes germinal center formation and isotope switching. CD40-CD40L seems to bridge innate and adaptive immune signals.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag




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Size Supplier No. VWR Catalog Number Unit Price Quantity
50 μg 90-395 75794-216 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Formulation Lyophilized from 0.2um-filtered solution in PBS.
Modification Fc Tag
Protein synonyms Gp39, CD154, Tumor Necrosis Factor Ligand Superfamily Member 5,TNFSF5
Protein type Recombinant
Protein/peptide name CD40 Ligand
Protein/peptide type Recombinant
Purity >98% (SDS-PAGE)
Sequence 113-261
Source CHO cells
Species Human
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
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