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CD68 Recombinant Protein, Prosci

Supplier: Prosci
CD68 is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells and in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 90-398 75794-222 Each (100µG) Retrieving Restricted
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SPECIFICATIONS

Protein/peptide name CD68
Protein synonyms GP110, SCARD1, Scavenger Receptor Class D Member 1, Macrosialin
Protein/peptide type Recombinant
Species Human
Source CHO cells
Sequence 22-319
Purity ≥98% (SDS-PAGE)
Formulation Lyophilized from 0.2um-filtered solution in PBS.
Biological activity Measured by its binding ability in a functional ELISA assay.
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Protein type Recombinant
Modification Fc Tag
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