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CD80 Recombinant Protein, Prosci

Supplier: Prosci
CD80 (B7-1) and CD86 (B7-2) together with their receptors CD28 and CTLA-4 constitute one of the dominant costimulatory pathways that regulate T cell and B cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon-gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily. It has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 90-401 75794-228 Each (100µG) Retrieving Restricted
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SPECIFICATIONS

Protein/peptide name CD80
Protein synonyms B7-1
Protein/peptide type Recombinant
Species Mouse
Source CHO cells
Sequence 37-245
Purity ≥98% (SDS-PAGE)
Formulation Lyophilized from 0.2um-filtered solution in PBS.
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Protein type Recombinant
Modification Fc Tag
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