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CD137 Recombinant Protein, Prosci

Supplier: Prosci

Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.

This recombinant proteins is for research use only.

Fusion-Tag: His Tag




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Size Supplier No. VWR Catalog Number Unit Price Quantity
25 μg 90-410 75794-246 Each (25µG) Retrieving Restricted
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SPECIFICATIONS

Protein/peptide name CD137
Protein synonyms 4-1BB, CDw137, MGC2172, T Cell Antigen ILA, Antigen 4-1BB Homolog, ILA, 4-1BB Ligand Receptor T Cell, TNFRSF9, CD137 Antigen, Tumor Necrosis Factor Receptor Superfamily Member 9
Protein/peptide type Recombinant
Species Human
Source E. coli
Sequence 19-184
Purity ≥95% (SDS-PAGE)
Formulation Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Protein type Recombinant
Modification His Tag
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