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CD152 [CTLA-4] non-lytic Recombinant Protein, Prosci

Supplier: Prosci

CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally
homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an
intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by
cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+
T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation.
Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag




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Size Supplier No. VWR Catalog Number Unit Price Quantity
500 μg 90-414 75794-254 Each (500µG) Retrieving Restricted
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SPECIFICATIONS

Biological activity Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells.
Formulation Lyophilized from 0.2um-filtered solution in PBS.
Modification Fc Tag
Protein synonyms CTLA-4, Cytotoxic T-lymphocyte Protein 4
Protein type Recombinant
Protein/peptide name CD152 non-lytic
Protein/peptide type Recombinant
Purity ≥98% (SDS-PAGE)
Sequence 37-160
Source CHO cells
Species Human
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
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