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CD152 [CTLA-4] Recombinant Protein, Prosci

Supplier: Prosci
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90-417
CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag


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Size Supplier No. VWR Catalog Number Unit Price Quantity
500 μg 90-417 75794-260 Each (500µG) Retrieving Restricted

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SPECIFICATIONS

Protein/peptide name CD152
Protein synonyms CTLA-4
Protein/peptide type Recombinant
Species Mouse
Source NS1 cells
Sequence 38-160
Purity >98% (SDS-PAGE)
Formulation Lyophilized from 0.2um-filtered solution in PBS.
Biological activity Binds both CD80 (B7-1) and CD86 (B7-2) with high affinity and inhibits CD28 signaling competitively. Kills the target cell completely.
Storage conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Protein type Recombinant
Modification Fc Tag
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