Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt), Premium Grade, Pierce™

Supplier: Thermo Scientific

Synonyms: Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium saltSulfo NHSHydroxy-2,5-dioxopyrrolidine-3-sulphonicacid sodium saltSulpho-N-HydroxysuccinimideSulfo-N-Hydroxysuccinimide

PG82071 PG82072 PG82071 PG82072
CAPIPG82071EA 781.56 CAD
CAPIPG82071 CAPIPG82072 PIPG82072 PIPG82071
Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt), Premium Grade, Pierce™
Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt)

Thermo Scientific Pierce Premium Grade Sulfo-NHS is our highest quality formulation of this N-hydroxysuccinimide chemical modification reagent, specially characterized for applications where product integrity and risk minimization are paramount.


  • Sulfo-NHS—use with EDC crosslinker to prepare amine-reactive NHS ester reagents
  • High quality—identity and purity confirmed by several tests, including quantitative NMR
  • Product integrity—enhanced level of testing and characterization compared to standard grade
  • Lot retention—ample supply of past lots retained to ensure future process testing
  • Change management—Change Control Notification (CCN) service
  • Consistent manufacture—batch-specific manufacturing documentation review


Compared to the standard grade product, Premium Grade Sulfo-NHS provides more clearly defined quality and product support by including (a) increased analytical testing and product characterization, (b) greater batch-specific information and quality assurance review, (c) extensive lot sample retention and (d) change control notification. Sulfo-NHS (N-hydroxysulfosuccinimide) enables control and modification of carbodiimide crosslinking reactions involving activation of carboxylates (—COOH) for conjugation with primary amines (—NH2). Derivatives are easily synthesized by mixing the sulfo-NHS with a carboxyl-containing molecule and a dehydrating agent such as the carbodiimide EDC (EDAC). The method is the basis for generating many types of protein labeling reagents, including amine-reactive fluorescent dyes, biotin affinity tags and pegylation compounds.


Caution: For Research Use Only. Not for use in diagnostic procedures.

Formula: C₄H₄NNaO₆S
MW: 217.13 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00043100
CAS Number: 106627-54-7

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Specification Test Results

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Carbodiimide
Spacer Short
Form Powder
Quantity 500 mg /10 g
Type Crosslinker
Solubility Water

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