Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt)

Supplier: G-Biosciences

Synonyms: Sulpho-NHSHydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium saltSulfo-NHSHydroxy-2,5-dioxopyrrolidine-3-sulphonicacid sodium saltSulpho-N-HydroxysuccinimideSulfo-N-Hydroxysuccinimide

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CA82022-866EA 889.02 CAD
CA82022-866 82022-866
Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt)
N-Hydroxysulfosuccinimide sodium salt (Sulfo-NHS)

G-Biosciences' Sulfo-NHS reacts primarily with primary amines to convert carboxyl groups to amine reactive sulfo-NHS esters


G-Biosciences' Sulfo-NHS is used to generate amine reactive esters from carboxylate groups and is primarily used to increase the efficiency of the carbodiimide EDC cross-linking. EDC reactions do not require G-Biosciences' Sulfo-NHS; however, its presence greatly enhances cross-linking efficiency and allows for a two-step process. EDC reacts with a carboxylate group to form an active ester, which is subject to rapid hydrolysis in aqueous buffers. The Sulfo-NHS increases the stability of the active intermediate and the resulting coupled product is identical to EDC reactions without sulfo-NHS.


G-Biosciences' Sulfo-NHS is water-soluble, long-lived, and hydrolyzes relatively slowly in water and in aqueous buffer, unlike NHS. Sulfo-NHS is offered as a 500 milligram supply. Formulation: N-Hydroxysulfosuccinimide. Molecular Formula: C₄H₄NNaO₆S.


It is ideal for cross-linking, chemical labeling and solid support immobilization.


Ordering information: Accessories available.

Formula: C₄H₄NNaO₆S
MW: 217.13 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00043100
CAS Number: 106627-54-7

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